Song Hongzhao (1915.08-2000.02) was a native of Suzhou, Jiangsu. He was gynecological oncologist. He graduated from Peking Union Medical College Hospital in 1943 and received his Ph. D. of Medicine from New York University. He was chief physician, vice dean and professor of Department of Gynecology of Peking Union Medical College Hospital. Concurrently he was honorary professor of Jinan University of Guangzhou, Chengdu Huaxi Medical University, Xi 'An Medical University. He served on the 6th National committee of the Chinese People's Political Consultative Conference, the national top advisory body, and also its 7th standing committee.
Prof. Song started research on birth control and made intrauterine device (IUD). He wrote China's first textbook on contraception. He had been engaged in research on gynecological tumor since 1950s and made breakthrough progress in treatment of highly malignant tumor ----Choriocarcinoma. He was the first one to use a large dose of chemical substance such as 6MP and 5FU to effect a radical cure of Choriocarcinoma, which was given National Science and Technology Progress Award, First Class in 1985. He was one of the major writers of a treatise: "Gestational Trophoblast Disease".
CURATIVE TREATMENT OF CHORIOCARCINOMA
Song Hongzhao
(Department of OB/GYN, Peking Union Medical College Hospital)
Abstract
Choriocarcinoma is a highly malignant cancer of women. It is characterized by early and widespread metastasis. Once it is diagnosed, patients usually die within one year. For a long time, there was no satisfactory treatment.
Since 1949, a comprehensive study of this disease has been carried out. Through an effort of nearly 40 years, several chemotherapeutic agents were proved to be very effective for this disease. Up to the end of 1985, a total of 1400 cases were treated. The mortality rate has been reduced from more than 90% to less than 15%. All survivors were followed up periodically for more than 5 years. Repeated examinations with modern techniques revealed no sign of residual disease, indicating that they are cured. Among them about one sixth belonged to very late cases with generalized metastases all over the body, including brain, lungs, liver, spleen, kidneys, and intestine. All have returned to work. About one fifth of the patients who were young and desirous of child-birth were treated with chemotherapy alone without removal of uterus. 86.7%of them became pregnant after recovery with a total of 387 live births. All babies are growing up normally. Twenty married and 15 gave birth to normal third generation. Cytogenetic study of the peripheral lymphocytes of one third of the second generation and half of the third generation randomizedly selected revealed no deviation from normal in chromosomal number and aberrations. The eldest grand-children was now 8 years old. There was no increase of incidence of obstetric problem of mother and incidence of recurrence.
Besides, some other studies were also conducted. The outstanding achievements are as follows.